The application of big data provides a new angle of view on investigating whether, and if so, here how to define the urban center through analyzing urban spatial morphology intrinsically interacts with its functions.This article, using empirical research of the Beijing city, first seeking to explore spatial configuration-the complex relation betwee

BackgroundBenign prostatic diseases (BPDs), such as benign prostate hyperplasia (BPH) and prostatitis, harm the quality of life of affected patients.However, observational studies exploring the association between thyroid function and BPDs have hitherto yielded inconsistent results.In this study, we explored whether there is a causal genetic associ

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The bacterial stringent response, triggered by nutritional deprivation, causes an accumulation of the signaling nucleotides pppGpp and ppGpp.We characterize the replication arrest that occurs during the stringent response in 6-0 igora vibrance Escherichia coli.Wild type cells undergo a RelA-dependent arrest after treatment with serine hydroxamate t